How much weight can I expect to lose on GLP-1s?

Addressing ‘How much weight loss on GLP-1’s’ is crucial for patients starting their weight loss journey.

Compounded GLP-1 medications from a tier one compounding pharmacy can lead to significant weight loss, but the amount varies widely based on individual factors such as starting weight, adherence to the medication, diet, exercise, duration of use, and whether it’s a single GLP-1 agonist or a dual GLP-1/GIP agonist formulation. In clinical trials, participants often achieve 10-20% body weight reduction over 6-18 months, but real-world results may be lower (around 5-10%) due to challenges like side effects or discontinuation. With personalized support from our medical team at Thrive Hormonal Health, many patients see results closer to trial averages through optimized dosing and lifestyle integration in our cash-based practice.

Many individuals wonder, ‘How much weight loss on GLP-1’s?’ This question often arises when discussing the effectiveness of these medications.

Expected Weight Loss in Clinical Trials

How much weight loss on GLP-1’s?

Understanding ‘How much weight loss on GLP-1’s’ can help set realistic expectations for those considering these therapies.

• • Single GLP-1 Agonists: These typically result in 10-15% average weight loss. For example, in a large trial, participants lost about 13.7% of body weight after 72 weeks. Meta-analyses confirm around 15-17% for formulations like semaglutide at higher doses.

It’s essential to consider ‘How much weight loss on GLP-1’s’ occurs in various studies to grasp its potential.

• • Dual GLP-1/GIP Agonists: These offer greater efficacy, with averages of 15-21%. In head-to-head studies, losses reached 20.2% at 72 weeks, outperforming single agonists.

When evaluating ‘How much weight loss on GLP-1’s’, it’s clear that dual GLP-1/GIP agonists show greater efficacy.

Real-World Expectations

Studies show real-world weight loss is often less impressive, averaging 4-9% after a year, as many stop treatment early (up to 50-75% within 12 months). However, those who persist with support achieve outcomes similar to trials—up to 15% or more. Factors like digital engagement or combined lifestyle programs can boost results by enhancing adherence.

Persistent treatment can lead to results that answer the question, ‘How much weight loss on GLP-1’s?’ effectively.

At Thrive Hormonal Health, our cash-based approach ensures access to high-quality compounded GLP-1 medications without insurance limitations, allowing for flexible adjustments to help you reach your goals safely. Results are not guaranteed and depend on your commitment, but our tier one pharmacy formulations and expert guidance often lead to sustainable losses of 10-20 pounds in the first few months, scaling up with time. Consult our team for a customized plan based on your health profile.

For those interested in weight management, knowing ‘How much weight loss on GLP-1’s’ is vital for making informed decisions.

Patients often inquire about ‘How much weight loss on GLP-1’s’ to determine their treatment course.

Citations:

[0] Real-world weight loss effectiveness of GLP-1 agonists among … – https://pmc.ncbi.nlm.nih.gov/articles/PMC9877131/[1] Real‐world evidence on the utilization, clinical and comparative … – https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.16364[2] Head-to-head Study Shows Bariatric Surgery Superior to GLP-1 … – https://asmbs.org/news_releases/head-to-head-study-shows-bariatric-surgery-superior-to-glp-1-drugs-for-weight-loss/[3] Real-World Results For GLP-1 Drugs Underwhelm, Study Says – https://www.usnews.com/news/health-news/articles/2025-06-11/real-world-results-for-glp-1-drugs-underwhelm-study-says[4] Think GLP-1s Guarantee Major Weight Loss? Real-World Data Says … – https://www.health.com/glp-1-drugs-real-world-weight-loss-11752679[5] Cleveland Clinic Research Finds Injectable Medications for Obesity … – https://newsroom.clevelandclinic.org/2025/06/10/cleveland-clinic-research-finds-injectable-medications-for-obesity-produce-smaller-weight-loss-in-a-real-world-setting-compared-to-randomized-clinical-trials[6] [PDF] Real-world trends in GLP-1 treatment persistence and prescribing … – https://www.bcbs.com/media/pdf/BHI_Issue_Brief_GLP1_Trends.pdf[7] The GLP-1 trend: What the real-world data reveals – https://blog.healthverity.com/the-glp-1-surge-what-the-real-world-data-reveals[8] Weight loss outcomes, tolerability, side effects, and risks – PMC – https://pmc.ncbi.nlm.nih.gov/articles/PMC11404059/[9] Real-world persistence and adherence to glucagon-like peptide-1 … – https://www.jmcp.org/doi/10.18553/jmcp.2024.23332[10] Semaglutide vs Tirzepatide for Weight Loss in Adults With … – https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2821080[11] Study: Real-world results of GLP-1 drugs don’t match trials – UPI.com – https://www.upi.com/Health_News/2025/06/11/study-results-glp1-drugs-trials/7461749647769/[12] Study Details | GLP-1 REceptor Agonists and Real World EvIdeNce – https://clinicaltrials.gov/study/NCT03959865[13] Long-term weight loss effects of semaglutide in obesity without … – https://www.nature.com/articles/s41591-024-02996-7[14] RWD study shows bariatric surgery leads to significantly greater … – https://becarispublishing.com/digital-content/blog-post/rwd-study-shows-bariatric-surgery-leads-significantly-greater-weight-loss-than-glp-1[15] Combined Effects of GLP-1 Analogue and Exercise on Maintenance … – https://clinicaltrials.gov/study/NCT04122716[16] Tirzepatide as Compared with Semaglutide for the Treatment of … – https://www.nejm.org/doi/full/10.1056/NEJMoa2416394[17] Real-World GLP-1 Weight-Loss Results Differ From Trials – Medscape – https://www.medscape.com/viewarticle/real-world-glp-1-weight-loss-results-differ-trials-2025a1000fih[18] One-Year Weight Reduction With Semaglutide or Liraglutide in … – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2823644[19] Cleveland Clinic Study IDs Factors Behind Long-Term Weight Loss … – https://newsroom.clevelandclinic.org/2024/09/13/cleveland-clinic-study-identifies-key-factors-that-can-impact-long-term-weight-loss-in-patients-with-obesity-who-were-prescribed-glp-1-ra-medications[20] Weight-Loss Medications Less Effective in the ‘Real World’: Study – https://people.com/weight-loss-medications-less-effective-in-the-real-world-study-11752745[21] Are the New Weight Loss Drugs Too Good to Be True? – https://magazine.ucsf.edu/weight-loss-drugs-too-good-to-be-true[22] Two-year effects of semaglutide in adults with overweight or obesity – https://www.nature.com/articles/s41591-022-02026-4[23] Study Shows Real World GLP-1 Weight Loss Results Less Than … – https://www.reddit.com/r/Zepbound/comments/1l90cvd/study_shows_real_world_glp1_weight_loss_results/[24] A Half Dose of Semaglutide Yields Weight Loss Equivalent to … – https://www.patientcareonline.com/view/a-half-dose-of-semaglutide-yields-weight-loss-equivalent-to-clinical-trial-doses-in-combination-with-online-support-program[25] Real-world research priorities for GLP-1 weight loss therapies in … – https://becarispublishing.com/digital-content/blog-post/real-world-research-priorities-glp-1-weight-loss-therapies-obesity-treatment[26] Prime Therapeutics GLP-1 research: Year-2 cost of care is $4200 … – https://www.primetherapeutics.com/w/prime-therapeutics-glp-1-research-year-2-cost-of-care-is-4-200-higher-for-patients-with-obesity[27] Triple–Hormone-Receptor Agonist Retatrutide for Obesity – https://www.nejm.org/doi/full/10.1056/NEJMoa2301972[28] New GLP-1 clinical trial results validate Truveta’s real-world data study – https://www.truveta.com/blog/data/clinical-trial-results-validate-truveta-rwd-study/[29] Real-world weight change, adherence, and discontinuation among … – https://drc.bmj.com/content/10/1/e002517

This research highlights significant data regarding ‘How much weight loss on GLP-1’s’ in various populations.